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psychoactive substances activate the mesolimbic dopaminergic pathway, but each does so through different mechanisms.

The mesolimbic dopaminergic pathway is located in an area of \u200b\u200bthe brain known and midbrain and is the most involved in the ability of dependence-producing psychoactive substances.

The cell bodies of these neurons send projections to brain regions involved in emotion, thought, memory and planning and execution of behaviors.

The nucleus accumbens is an important brain area that is involved in motivation and learning and in pointing the motivational value of stimuli. Psychoactive substances increase the release of dopamine in the nucleus accumbens and believes this is an important event in the reinforcement.

has been shown that the path mesolimbic dopamine is heavily involved in motivational processes, which means that the brain attaches particular importance to stimuli recognized as important for survival.

The motivation is the allocation of attentional and behavioral stimuli according to their predicted consequences.

Incentives are stimuli that elicit a response based on their predicted consequences. In

dependence, psychoactive substances repeatedly activate the motivational systems of the brain that are normally activated by stimuli important as food, water, danger, and the couple. With

Chronic use of marijuana is described the "syndrome amotivational" where the person loses ineteres for life.

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Neurobiology of Addictions, Learning and Behavioral Neurobiology and Behavior

The development of dependence can be considered as part of a learning process in the sense that the interactions between psychoactive substances and environments associated with them produce lasting behavioral changes.

stimuli associated with food, water and the couple, they activate specific pathways and reinforce behaviors that lead to achieving the respective goals.

Psychoactive drugs artificially activate these same pathways, but very intense, leading to increased motivation to continue with this behavior.

Thus, the dependence is the result of a complex interplay of physiological effects of substances on brain areas associated with pleasure, motivation and emotion, combined with learning about the relationship between substances and related signals them.

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The brain is tricked by substances that can get you to respond as if these stimuli and were biologically related to them necessary.

As exposure is repeated, the association is becoming stronger and produces a behavioral and neurochemical response growing. This is known as sensitization the incentive, and consists in the fact that psychoactive substances and stimuli associated with their consumption, for example where consumed, the people consumed, the music you hear when conume, are increasingly more motivational and behavioral .

Through associative learning processes, motivation to consume drugs may be strongly activated by stimuli (environments, people, objects) from the use of the substance, causing the intense desire that can beat the person and have re- take the substance, even after long periods of abstinence.